pentobarbital will lessen the extent or result of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the extent or effect of doxorubicin liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will minimize the level or influence of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Lowered AUC of tramadol and the active metabolite (O-desmethyltramadol) when coadministered with powerful CYP3A4 and CYP2B6 inducers
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Keep track of. Drugs that increase delta-aminolevulinic acid synthetase could minimize hemin influence.
Phenobarbital is revealed to shorten the half-life of doxycycline for so long as 2 months right after barbiturate therapy is discontinued. This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic.
Caution needs to be exercised when barbiturates are administered to individuals with acute or chronic pain, mainly because paradoxical exhilaration may very well be induced or vital indications can be masked.
pentobarbital will lessen the extent or influence of triamcinolone acetonide injectable suspension by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
fentanyl iontophoretic transdermal technique and pentobarbital both raise sedation. Stay clear of or Use Alternate Drug. Restrict use to people for whom alternative therapy choices are inadequate
pentobarbital will lower the level or result of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital will minimize the level or result of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the extent or outcome of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
Clinical reports of Nembutal haven't provided ample figures of topics aged 65 and about to determine no matter if elderly topics answer in different ways from young subjects. Other documented scientific expertise hasn't discovered distinctions in responses involving the elderly and more youthful clients.
pentobarbital will lessen the level or effect of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Pitolisant exposure is lowered by 50% if coadministered with potent CYP3A4 inducers.
Maximal CNS check here melancholy may well not arise until quarter-hour or more soon after IV administration for phenobarbital sodium.